Publications

Barnoud T, Parris JLD, Murphy ME. Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism. Oncotarget. 2019 Feb 5;10(11):1217-1223. doi: 10.18632/oncotarget.26660. eCollection 2019 Feb 5. PubMed PMID: 30838093; PubMed Central PMCID: PMC6383823.

Basu J, Reis BS, Peri S, Zha J, Hua X, Ge L, Ferchen K, Nicolas E, Czyzewicz P, Cai KQ, Tan Y, Fuxman Bass JI, Walhout AJM, Grimes HL, Grivennikov SI, Mucida D, Kappes DJ. Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function. 2021 Nat Immunol. 22:969-982. PMCID: PMC8887595.

Basu J, Zha J, Nicolas E, Coulton M, Czyzewicz P, Hua X, Ge L, Kappes DJ. An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. 2022 Commun Biol. 5:84. PMCID: PMC8783009.

Binder P, Wang S, Radu M, Zin M, Collins L, Khan S, Li Y, Sekeres K, Humphreys N, Swanton E, Reid A, Pu F, Oceandy D, Guan K, Hille SS, Frey N, Müller OJ, Cartwright EJ, Chernoff J, Wang X, Liu W. Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circ Res. 2019 Mar;124(5):696-711. doi: 10.1161/CIRCRESAHA.118.312829. PMID: 30620686.

Chow HY, Dong B, Valencia CA, Zeng CT, Koch JN, Prudnikova TY, Chernoff J. Group I Paks are essential for epithelial-mesenchymal transition in an Apc-driven model of colorectal cancer. 2018 Nature Communications 9:3473. PMCID: PMC6110733

Fahl, S.P., Coffey, F., Kain, L., Zarin, P., Teyton, L., Zúñiga-Pflücker, J.C., Kappes, D.J., and Wiest, D.L. Role of a selecting ligand in shaping the gamma delta TCR repertoire. 2018. Proc Natl Acad Sci U S A. 115:1889-1894. PMC5828614

Gabbasov R, Xiao F, Howe CG, Bickel LE, O'Brien SW, Benrubi D, Do TV, Zhou Y, Nicolas E, Cai KQ, Litwin S, Seo S, Golemis EA, Connolly DC. NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice. 2018 Oncogene. 37:4854-4870. PMCID: PMC6119087.

Gupta S, Gallego-Villar L, Wang L, Lee HO, Nasrallah G, Al-Dewik N, Häberle J, Thöny B, Blom HJ, Ben-Omran T, Kruger WD. Analysis of the Qatari R336C cystathionine β-synthase protein in mice. J Inherit Metab Dis. 2019 Sep;42(5):831-838. doi: 10.1002/jimd.12140. Epub 2019 Jul 10. PMID: 31240737

Hasan N, Pangeni G, Ray TA, Fransen KM, Noel J, Borghuis BG, McCall MA, Gregg RG. LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF Pathway Signaling in the Retina. eNeuro. 2020 Jan/Feb;7(1). doi: 10.1523/ENEURO.0002-20.2020. Print 2020 Jan/Feb. PubMed PMID: 31959619; PubMed Central PMCID: PMC7031853.

Hayakawa, K., Formica, A.M., Zhou, Y., Ichikawa, D., Asano, M., Li, Y.S., Shinton, S.A., Brill-Dashoff, J., Nunez, G., Hardy, R.R. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. 2017. J. Exp. Med. 214:3067-83, PMCID: PMC5626402.

Hayakawa K, Li YS, Shinton SA, Bandi SR, Formica AM, Brill-Dashoff J, Hardy RR. Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. Front Immunol. 2019 Mar 15;10:457. doi: 10.3389/fimmu.2019.00457. eCollection 2019. PMID: 3093089

Karakashev S, Fukumoto T, Zhao B, Lin J, Wu S, Fatkhutdinov N, Park PH, Semenova G, Jean S, Cadungog MG, Borowsky ME, Kossenkov AV, Liu Q, Zhang R. EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition. 2020 Cancer Cell. 37:157-167, PMCID: PMC7155421.

Krais JG, Wang Y , Patel P, Basu J, Bernhardy AJ, Johnson N. RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage. Nat Commun. 2021 Aug 18;12(1):5016. doi: 10.1038/s41467-021-25346-4.

Kukuyan, A.M., Sementino, E., Kadariya, Y., Menges, C.W., Cheung, M., Tan, Y., Cai, K.Q., Slifker, M.J., Peri, S., Klein-Szanto, A.J., Rauscher, F.J. 3rd, Testa, J.R. Inactivation of Bap1 cooperates with losses of Nf2 and Cdkn2a to drive the development of pleural malignant mesothelioma in conditional mouse models. 2019. Cancer Res. 79:4113-4123, PMCID: PMC6697648.

Lee HO, He X, Mookerjee-Basu J, Zhongping D, Hua X, Nicolas E, Sulis ML, Ferrando AA, Testa JR, Kappes DJ. Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas. 2015. Proc Natl Acad Sci U S A. 112:7773-8, PMCID: PMC4485124.

Lee HO, Gallego-Villar L, Grisch-Chan HM, Häberle J, Thöny B, Kruger WD. 2019. Treatment of Cystathionine β-Synthase Deficiency in Mice Using a Minicircle-Based Naked DNA Vector. Hum Gene Ther. Sep;30(9):1093-1100. doi: 10.1089/hum.2019.014. Epub 2019 Jun 13. PMID: 31084364

Leu JI, Murphy ME, George DL. Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53. Proc Natl Acad Sci U SA. 2019 Apr 23;116(17):8390-8396. doi: 10.1073/pnas.1821277116. Epub 2019 Apr 8. PubMed PMID: 30962386; PubMed Central PMCID: PMC6486733.

Mancuso P, Tricarico R, Bhattacharjee V, Cosentino L, Kadariya Y, Jelinek J, Nicolas E, Einarson M, Beeharry N, Devarajan K, Katz RA, Dorjsuren DG, Sun H, Simeonov A, Giordano A, Testa JR, Davidson G, Davidson I, Larue L, Sobol RW, Yen TJ, Bellacosa A. Thymine DNA glycosylase as a novel target for melanoma. Oncogene. 2019 May;38(19):3710-3728. doi: 10.1038/s41388-018-0640-2. Epub 2019 Jan 23. PMID: 30674989

Mookerjee-Basu J, Hua X, Ge L, Nicolas E, Li Q, Czyzewicz P, Zhongping D, Peri S, FuxmanBass JI, Walhout AJM, Kappes DJ. Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age. Mol Biol Evol. 2019 Jan 1;36(1):39-53. doi: 10.1093/molbev/msy191. PMID: 30295892

Muench DE, Olsson A, Ferchen K, Pham G, Serafin RA, Chutipongtanate S, Dwivedi P, Song B, Hay S, Chetal K, Trump-Durbin LR, Mookerjee-Basu J, Zhang K, Yu JC, Lutzko C, Myers KC, Nazor KL, Greis KD, Kappes DJ, Way SS, Salomonis N, Grimes HL. Mouse models of neutropenia reveal progenitor-stage-specific defects. 2020 Nature. 582:109-114. PMCID: PMC8041154.

Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, Johnson N. BRCA1 Mutational Complementation Induces Synthetic Viability. 2020 Molec. Cell. 78:951-959. PMCID: PMC7418109.

Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG. The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network. Sci Immunol. 2019 Feb 15;4(32):eaal2201. doi: 10.1126/sciimmunol.aal2201. PMID: 30770409

Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. 2020 Science. 369:942-949; PMCID: PMC7646930.

Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR. Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Mol Cancer Res. 2022 May 4;20(5):699-711. doi: 10.1158/1541-7786.MCR-21-0837. PMID: 35082167.

Sertori. S., Lin, J.-X., Sharo, A., Kazemian, M., Sunderam, U., Rana, S., Andrake, M., Martinez, E, Shinton, S., Truong, B., Dunbrack, R.M., Liu, C., Brenner, S., Seroogy, C.M., Puck, J., Leonard, W.J., Wiest, D.L. 2022. Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency. Frontiers in Immunol. 13:928252; doi: 10.3389/fimmu.2022.928252; PMC: PMC9372720

Shinton SA, Brill-Dashoff J, Hayakawa K. Pla2g2a promotes innate Th2-type immunity lymphocytes to increase B1a cells. Sci Rep. 2022 Sep 1;12(1):14899. doi: 10.1038/s41598-022-18876-4. PMID: 36050343 PMCID: PMC9437038 DOI: 10.1038/s41598-022-18876-4

Tricarico R, Madzo J, Scher G, Cohen M, Jelinek J, Maegawa S, Nagarathinam R, Scher C, Chang WC, Nicolas E, Slifker M, Zhou Y, Devarajan K, Cai KQ, Kwok T, Nakajima P, Xu J, Mancuso P, Doneddu V, Bagella L, Williams R, Balachandran S, Maskalenko N, Campbell K, Ma X, Cañadas I, Viana J, Moreno V, Valle L, Grivennikov S, Peshkova I, Kurilenko N, Mazitova A, Koltsova E, Lee H, Walsh M, Duttweiler R, Whetstine JR, Yen TJ, Issa JP, Bellacosa A.TET1 and TDG suppress inflammatory response in intestinal tumorigenesis: implications for colorectal tumors with the CpG Island Methylator Phenotype. Gastroenterology. 2023 May;164(6):921-936.e1. doi: 10.1053/j.gastro.2023.01.039. Epub 2023 Feb 8. PMID: 36764492

Zhang Y, Truong B, Fahl SP, Martinez E, Cai KQ, Al-Saleem ED, Gong Y, Liebermann DA, Soboloff J, Dunbrack R, Levine RL, Fletcher S, Kappes D, Sykes SM, Shapiro P, Wiest DL. The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasm. Blood. 2022 Jul 28;140(4):359-373. doi: 10.1182/blood.2021013068. PMID: 35436326