Publications

Chow, H.-Y., Karchugina, S., Groendyke, B. J., Toenjes, S., Hatcher, J., Donovan, K. A., Chernoff, J. (2022). Development and Utility of a PAK1-Selective Degrader. Journal of Medicinal Chemistry, 65(23), 15627-15641. doi:10.1021/acs.jmedchem.2c00756    

Kurimchak AM, Herrera-Montávez C, Montserrat-Sangrà S, Araiza-Olivera D, Hu J, Neumann-Domer R, Kuruvilla M, Bellacosa A, Testa JR, Jin J, Duncan JS. The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells. Sci Signal. 2022 Aug 30;15(749):eabn2707. doi: 10.1126/scisignal.abn2707

Kozinova M., Joshi S., Ye S., Belinsky M.G., Sharipova D., Farma J.M., Reddy S.S., Litwin S., Devarajan K., Campos A.R., Yu Y., Schwartz B., von Mehren M., Rink L. (2021) Combined inhibition of AKT and KIT restores expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor. Cancers, July 23;13(15):3699. 

Ye S., Sharipova D., Kozinova M., Klug L.R., D’Souza J.W., Belinsky M.G., Johnson K.J., Einarson M.B., Devarajan K., Zhou Y., Litwin S., Heinrich M.C., DeMatteo R.P., von Mehren M., Duncan J.S., Rink, L. (2021) Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment. JCI Insight. Jan 25;6(2):e143474. PMCID: PMC7934848

Alexander JI, Vendramini-Costa DB, Francescone, R, Luong, T., Franco-Barraza, J., Shah, N., Gardiner, JC, Nicolas, E. Raghavan, KS, Cukierman, E. Palladin isoforms 3 and 4 regulate cancer associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma. Sci Rep. 11:3802. 2021,

Cho EA, Zhang P, Kumar V, Kavalchuk M, Zhang H, Huang Q, Duncan JS, Wu J. Phosphorylation of RIAM by Src promotes integrin activation by unmasking the PH domain of RIAM. Structure. 2021 Apr 1;29(4):320-329.e4. doi: 10.1016/j.str.2020.11.011. 

Makhov, P., Bychkov, I., Faezov, B., Deneka, A., Kudinov, A., Nicolas, E., Brebion, R., Avril, E., Cai, K.Q., Kharin, L., Volosshin, M., Frantsiyants, E., Karnaukhov, N., Kit, Topchu, I., O.I., Fazliyeva, R., Nikonova, A.S., Serebriiskii, I.G., Borghaei, H., Edelman, M., Dulaimi, E., Golemis, E.A., and Boumber., Y.  Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Oncogenesis. 2021 Mar 15;10(3):29, 

Sun, D., Nikonova, A.S., Zhang, P., Deneka, A.Y., Fitzgerald, M., Michael, R., Lee, L., Lilly, A., Fisher, S., Phillips, A., Nasveschuk, C.G., Proia, D.A., Tu, Z., and Golemis, E.A. Evaluation of the small-molecule BRD4-degrader CFT-2718 in small cell lung cancer and pancreatic cancer models. Mol Cancer Ther, 2021 Aug;20(8):1367-1377. 

Zhang, P., Kiseleva, A.A., Korobeynikov, V., Liu, H., Einarson, M.B., Golemis, E.A.  Microscopy-based automated live cell screening for small molecules that affect ciliation.  Front Genet. 10:75, 2019. 

Tricarico, R., Madzo, J., Scher, G., Maegawa, S., Jelinek, J., Scher, C., Chang, W.C., Nicolas, E., Zhou, Y., Slifker, M., Devarajan, K., Cai, K.Q., Nakajima, P., Xu, J., Mancuso, P., Doneddu, V., Bagella, L., Ingram, J., Balachandran, S., Peshkova, I., Koltsova, E., Grivennikov, S., Yen, T.J., Issa, J.P., Bellacosa, A.  TET1 and TDG suppress intestinal tumorigenesis by down-regulating the inflammatory and immune response pathways. BioRxiv MS ID#: BIORXIV/2019/676445: 2019.