Publications

Tricarico, R., Madzo, J., Scher, G., Cohen, M., Jelinek, J., Maegawa, S., Nagarathinam, R., Scher, C., Chang, W.C., Nicolas, E., Slifker, M., Zhou, Y., Devarajan, K., Cai, K.Q., Kwok, T., Nakajima, P., Xu J., Mancuso, P., Doneddu., V., Bagella, L., Williams, R., Balachandran, S., Maskalenko, N., Campbell, K., Ma, X., Cañadas, I., Viana, J., Moreno, V., Valle, L., Grivennikov, S, Peshkova, I., Kurilenko, N., Mazitova, A., Koltsova, E., Lee, H., Walsh, M., Duttweiler, R., Whetstine, J.R., Yen, T.J., Issa, J.P., and Bellacosa, A. TET1 and TDG suppress inflammatory response in intestinal tumorigenesis: implications for colorectal tumors with the CpG island methylator phenotype. Gastroenterology 2023; 164:921-36.e1. PMCID: PMC10586516

Gray, ZH, Chakraborty, D, Duttweiler, RR, Alekbaeva, GD, Murphy, SE, Chetal, K, Ji, F, Ferman, BI, Honer, MA, Wang, Z, Myers, C, Sun, R, Kaniskan, HU, Toma, MM, Bondarenko, EA, Santoro, JN, Miranda, C,

Dillingham, ME, Tang, R, Gozanim, O, Jin, J, Skorski, T, Duy, C, Lee, H, Sadreyvev, RI, Whetstine, JR. Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell 2023;186:4528-45. PMCID: PMC10591855

Krais, JJ, Glass, DJ, Chudoba, I, Wang, Y, Feng, W, Simpson, DA, Patel, P, Liu, Z, Neumann-Domer, R, Betsch, RG, Bernhardy, AJ, Bradbury, AM, Conger, J, Yueh, W, Nacson, J, Pomerantz, RT, Gupta, GP, Testa, JR, Johnson, N. Genetic separation of Brca1 functions reveal mutation-dependent Polq vulnerabilities. Nature Commun 2023;14:7714. PMCID: PMC10673838

Wei, W, Song, Z, Chiba, M, Wu, W, Jeong, S, Zhang, JP, Kadin, ME, Nakagawa, M, Yang, Y. Analysis and therapeutic targeting of the EP300 and CREBBP acetyltransferases in anaplastic large cell lymphoma and Hodgkin lymphoma. Leukemia 2023;37:396-407. PMCID: PMC9949602

Zhang, T, Yin, C, Fedorov, A, Qiao, L, Bao, H-L, Beknazarov, N, Wang, S, Gautam, A, Williams, RM, Crawford, JC, Peri, S, Studitsky, V, Beg, AA, Thomas, PG, Walkley, C, Xu, Y, Poptsova, M, Herbert, A, Balachandran, S. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis. Nature 2022;606:594-602. PMCID: PMC9373927

Kurimchak, AM, Herrera-Montávez, C, Montserrat-Sangrà, S, Araiza-Olivera, D, Hu, J, Neumann-Domer, R, Kuruvilla, M, Bellacosa, A, Testa, JR, Jin, J, Duncan, JS. The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells. Sci Signal 2022; 15:eabn2707. PMCID: PMC9552188

Krais, JJ, Wang, Y, Patel, P, Basu, J, Bernhardy, AJ, Johnson, N. RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage. Nat Commun 2021;12:5016. PMCID: PMC8373961

Zhao, Z., Fowle, H., Valentine, H., Liu, Z., Tan, Y., Pei, J., Badal, S., Testa, J.R., Graña, X.  Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase.  Prostate Cancer Prostatic Dis. 2021, 24: 233–243. PMCID: PMC7917161.

Francescone, R., Vendramini-Costa, D.B., Franco-Barraza, J., Wagner, J., Muir, A., Lau, A.N., Gabitova, L., Pazina, T., Gupta, S., Luong, T., Shah, N., Rollins, D., Malik, R., Thapa, R., Restifo, D., Zhou, Y., Cai, K.Q., Hensley, H.H., Tan, Y., Kruger, W.D., Devarajan, K., Balachandran, S., Klein-Szanto, A.J., El-Deiry, W.S., Vander Heiden, M.G., Peri, S., Campbell, K.S., Astsaturov, I., and Cukierman, E.  Netrin G1/NGL-1 axis promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. 2020. Cancer Discov. 11:446-479, PMCID: PMC7858242.

Gabitova-Cornell, L., Surumbayeva, A., Peri, S., Franco-Barraza, J., Restifo, D., Weitz, N., Ogier,. C, Goldman, A.R., Hartman, T.R., Francescone, R., Tan, Y., Nicolas, E., Shah, N., Handorf, E.A., Cai, K.Q., O'Reilly, A.M., Sloma, I., Chiaverelli, R., Moffitt, R.A., Khazak, V., Fang, C.Y., Golemis, E.A., Cukierman, E., Astsaturov, I. Cholesterol pathway inhibition induces TGF-β signaling to promote basal differentiation in pancreatic cancer. 2020 Cancer Cell 38:567-583, PMCID: PMC7572882.

Nacson J., Di Marcantonio, D., Wang., Y., Bernhardy, A.J., Clausen, E., Hua, X., Cai, K.Q., Martinez, E., Feng, W., Callén, E., Wu, W., Gupta, G.P., Testa, J.R., Nussenzweig, A., Sykes, S.M., Johnson, N.  BRCA1 mutational complementation induces synthetic viability. 2020 Mol. Cell 78:951-959. PMCID: PMC7418109. 

Zhang, T., Yin, C., Boyd, D.F., Quarato, G., Ingram, J.P., Shubina, M., Ragan, K.B., Ishizuka, T., Chase Crawford, J., Tummers, B., Rodriguez, D.A., Xue, J., Peri, S., Kaise, W.J., López, C.B., Xu, Y., Upton, J.W., Thomas, P.G., Green, D.R., Balachandran, S. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. 2020 Cell 180:1115-1129. PMCID: PMC7153753.