Margaret von Mehren, MD

Margaret Von Mehren
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Clinical Locations

Chief, Division of Sarcoma Medical Oncology 

Vice Chair, Department of Hematology/Oncology

Physician Director, Clinical Trials Office

Associate Director, Clinical Research

Professor, Department of Hematology/Oncology

NCCN, Adolescent and Young Adult Oncology Panel Member

NCCN, Soft Tissue Sarcoma Panel Member

Specialties

Treatment Focus

Chemotherapy; tyrosine kinase therapy; immunotherapy

Research Program

Key Awards

2023 top doctors
Medical Oncology

Treatment Philosophy

I first had the opportunity to treat patients with sarcoma during my oncology fellowship training. I really enjoyed the challenge of this area of oncology because of the many types of tumors and their rarity.  When I meet a patient, I work to be certain the pathologic diagnosis is correct and address what we need to do to treat the disease. I collaborate with Fox Chase pathologists, radiologists, surgeons, radiation oncologists and social workers to develop the right treatment plan. We meet as a team weekly at the Sarcoma multi-disciplinary tumor board to review individual patient cases and agree on the best management.

I am also committed to developing new therapies for patients with sarcomas. The strides made in improving cancer care have come from research and clinical trials. I work closely with scientists to better understand gastrointestinal stromal tumors and other sarcomas. I aim to have research studies as a treatment option for my sarcoma patients.

Educational Background

  • Fellow, Hematology/Oncology, Fox Chase Cancer Center and Temple University, Philadelphia, PA
  • Resident, Internal Medicine, New York University Medical Center, NY
  • MD, Albany Medical College, Albany, NY, 1989
  • BS, Biology, Georgetown University, Washington, DC, 1985

Certifications

  • Oncology, Board Certified, 1997, 2007
  • Internal Medicine, Board Certified, 1993

Memberships

  • National Comprehensive Cancer Network (NCCN)
    • Adolescent and Young Adult Oncology Panel
    • JNCCN Editorial Board
    • Soft Tissue Sarcoma Panel
  • American Society of Clinical Oncology
  • American Association of Cancer Research
  • Eastern Cooperative Oncology Group
  • Connective Tissue Oncology Society
  • Intergroup Coalition Against Sarcomas, 2003-2007
  • Sarcoma Alliance through Research and Collaboration
  • Medical Advisory and Editorial Board of the of the Liddy Shriver Sarcoma Initiative, 2010-201

Honors & Awards

  • Philadelphia Magazine Top Doctors, 2006-2022
  • Best Doctors in America® , 2013-14, 2019-2020, Medical Oncology and Urology
  • America’s Top Doctors®, 2015-17
  • Co-Chairman, 2013 GIST NET Global Opinion Leader Summit, Helsinki, FI, 2013
  • Co-Chairman, 2008 GIST Global Opinion Leader Summit, Warsaw, Poland, 2008
  • Clinical Investigator Training Program K-12 Award, Fox Chase Cancer Center, 1996-1998
  • Kenneth B. Olsen Prize, The Lamb Foundation, Inc., 1989
  • Amgen Fellowship Scholarship, American Association of Cancer Research, 1986

Michelle Palandro

  • Sarcoma

Michelle Palandro was a healthy and active 27-year-old woman when she was diagnosed with liposarcoma. After first meeting with an oncologist at a large teaching hospital, Michelle was not convinced that this was the best place for her treatment. She sought a second opinion and was pleased with the compassion and thoroughness of the treatment team at Fox Chase. After undergoing surgery, chemotherapy, and radiation therapy, Michelle is happy to report that she has been cancer free since 2012, and that she gave birth to a healthy baby boy in 2015. "At Fox Chase, every single person I met and every single nurse who took care of me was exceptional."

VIEW PATIENT STORY

John St. Omer

  • GIST (Gastrointestinal Stromal Tumor)

In the spring 2005, I passed out at my home and was taken to my local emergency room. After describing my symptoms, an endoscopy was performed. Doctors found a mass in my stomach and performed laparoscopic surgery to remove it. My discharge instructions made no mention of cancer.

In April 2007, my symptoms were back, so I returned to the same hospital. The doctors asked me whether I followed up with an oncologist after my initial surgery. No one at my local hospital ever told me I had cancer, so I was confused and shocked by this news.

VIEW PATIENT STORY

Warren Chambers

  • GIST (Gastrointestinal Stromal Tumor)

My body’s call for medical attention came on a seemingly normal morning in 2007, when I experienced extreme difficulty swallowing after completing my regular workout routine. I had an uneasy feeling about the strange sensation, but I delayed pursuing a doctor’s help until the next day, when I finally decided to go to the emergency room at a local hospital. The emergency room doctor found a large growth in my stomach and recommended that I seek a facility that was able to handle a tumor of that type and size. I was shocked that I could be living with something and not know. I was able to run five miles the previous day with no issues.

VIEW PATIENT STORY

Research Interests

  • Soft tissue and bone sarcomas
  • Gastrointestinal stromal tumors
  • Drug development
  • Clinical trials

Selected Publications

Blay J.Y., Kang Y.K., Nishida T.,von Mehren M., Gastrointestinal stromal tumours. Nat Rev Dis Primers. 7(1): 22, 2021. https://www.ncbi.nlm.nih.gov/pubmed/33737510.

von Mehren M., George S., Heinrich M.C., Schuetze S.M., Yap J.T., Yu J.Q., Abbott A., Litwin S., Crowley J., Belinsky M., Janeway K.A., Hornick J.L., Flieder D.B., Chugh R., Rink L.A.,Van den Abbeele A.D., Linsitinib (osi-906) for the treatment of adult and pediatric wild type gastrointestinal stromal tumors, a sarc phase ii study. Clin Cancer Res. 26(8): 1837-1845, 2020. PMC7856429. https://www.ncbi.nlm.nih.gov/pubmed/31792037.

Patel D, Handorf E, von Mehren M, Martin L, Movva S. Adjuvant Chemotherapy in Uterine Leiomyosarcoma: Trends and Factors Impacting Usage. Sarcoma, 2019:3561501, 2019. PMC6387708

Calvo E, Azaro A, Rodon J, Dirix L, Huizing M, Senecal FM, LoRusso P, Yee L, Poggesi I, de Jong J, Triantos S, Park YC, Knoblauch RE, Parekh TV, Demetri GD, von Mehren M. Hepatic safety analysis of trabectedin: results of a pharmacokinetic study with trabectedin in patients with hepatic impairment and experience from a phase 3 clinical trial. Investigational new drugs, 36(3):476-86, 2018. PubMed

Moten AS, Movva S, von Mehren M, Wu H, Esnaola NF, Reddy SS, Farma JM. Granular cell tumor experience at a comprehensive cancer center. J Surg Res, 226:1-7, 2018. PubMed

von Mehren M, Joensuu H. Gastrointestinal Stromal Tumors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 36(2):136-43, 2018. ascopubs.org

Movva S, Wen W, Chen W, Millis SZ, Gatalica Z, Reddy S, von Mehren M, Van Tine BA. Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets. Oncotargets 2015 Mar 26. [Epub ahead of print]. PubMed

von Mehren M, Bookman M, Meropol N, Weiner L, Sherman E, Li J, Knoblauch R, Parekh T, Cohen R. Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies. Cancer Chemotherapy and Pharmacology, 75(5):1047-55, 2015. PubMed

von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU 3rd, DeLaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM 3rd, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H. Gastrointestinal stromal tumors, version 2.2014. Journal of the National Comprehensive Cancer Network, 12(6):853-62, 2014. PubMed

von Mehren M, Randall RL, Benjamin RS, Boles S, Bui MM, Casper ES, Conrad EU, DeLaney TF, Ganjoo KN, George S, Gonzalez RJ, Heslin MJ, Kane JM, Mayerson J, McGarry SV, Meyer C, O'Donnell RJ, Pappo AS, Paz IB, Pfeifer JD, Riedel RF, Schuetze S, Schupak KD, Schwartz HS, Van Tine BA, Wayne JD, Bergman MA, Sundar H. Soft Tissue Sarcoma, Version 2.2014 Featured Updates to the NCCN Guidelines. Journal of the National Comprehensive Cancer Network, 12(4):473-83, 2014... Expand

Additional Publications

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