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- Yan Zhou
Yan Zhou, PhD, MSE

Associate Research Professor
Research Program
Lab Overview
Work closely with biologists as well as clinical research teams to identify critical questions that can be addressed via computational approaches. Define and implement computational analysis plans to advance our research in cancer biology and also the development of potential novel translational therapeutic agents.
Analysis of various –omic-scale data including RNA-Seq, Exome and Whole Genome Sequencing and high throughput screening in order to nominate novel drug targets, enable patient enrichment strategies, understand mechanisms of resistance to therapies.
Integration and mining of large scale external data sets (TCGA, 1KG, EXAC, Cosmic) to further our understanding of the relationship between tumor genetics, the tumor microenvironment, and response to therapies.
Educational Background
- MSE, Biotechnology, University of Pennsylvania, Philadelphia, PA, 2002
- PhD, Biochemistry, Institute of Basic Medical Sciences, CAMS&PUMC, Beijing, 1999
- BS, Molecular Biology, Nankai University, Tianjin, China, 1994
Memberships
- International Society of Computational Biology and Bioinformatics
Research Interests
- Implement computational and statistical methods to analyze and interpret complex, high-throughput biological and genomic data
- Apply the most advanced pathway and network analysis to elucidate the perturbation of cellular mechanisms through observed genomic changes in different biological and disease conditions
Selected Publications
Pathak HB, Zhou Y, Sethi G, Hirst J, Schilder RJ, Golemis EA, Godwin AK. A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer. PLoS One. 2015 Dec 4;10(12):e0144126. PubMed PMID: 26637171; PubMed Central PMCID: PMC4670180.
Li YS, Zhou Y, Tang L, Shinton SA, Hayakawa K, Hardy RR. A developmental switch between fetal and adult B lymphopoiesis. Ann N Y Acad Sci. 2015 Dec;1362:8-15. doi: 10.1111/nyas.12769. Epub 2015 Apr 30. Review. PubMed PMID: 25931205.
Arora S, Yan H, Cho I, Fan HY, Luo B, Gai X, Bodian DL, Vockley JG, Zhou Y, Handorf EA, Egleston BL, Andrake MD, Nicolas E, Serebriiskii IG, Yen TJ, Hall MJ, Golemis EA, Enders GH. Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial Colorectal Carcinomas. Gastroenterology. 2015 Dec;149(7):1872-1883.e9. PubMed PMID: 26344056; PubMed Central PMCID: PMC4663158.
Plimack ER, Dunbrack RL, Brennan TA, Andrake MD, Zhou Y, Serebriiskii IG, Slifker M, Alpaugh K, Dulaimi E, Palma N, Hoffman-Censits J, Bilusic M, Wong YN, Kutikov A, Viterbo R, Greenberg RE, Chen DY, Lallas CD, Trabulsi EJ, Yelensky R, McConkey DJ, Miller VA, Golemis EA, Ross EA. Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer. Eur Urol. 2015 Dec;68(6):959-67. PubMed PMID: 26238431; PubMed Central PMCID: PMC4764095.
Nicolas E, Arora S, Zhou Y, Serebriiskii IG, Andrake MD, Handorf ED, Bodian DL, Vockley JG, Dunbrack RL, Ross EA, Egleston BL, Hall MJ, Golemis EA, Giri VN, Daly MB. Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer. Oncotarget. 2015 Nov 24;6(37):39614-33. PubMed PMID: 26485759; PubMed Central PMCID: PMC4741850.
Bhattacharjee V, Zhou Y, Yen TJ. A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle. 2014;13(24):3839-56. PubMed PMID: 25558828; PubMed Central PMCID: PMC4615005.
Gowrishankar B, Ibragimova I, Zhou Y, Slifker MJ, Devarajan K, Al-Saleem T, Uzzo RG, Cairns P. MicroRNA expression signatures of stage, grade, and progression in clear cell RCC. Cancer Biol Ther. 2014 Mar 1;15(3):329-41. PubMed PMID: 24351440; PubMed Central PMCID: PMC3974834.
Rink L, Ochs MF, Zhou Y, von Mehren M, Godwin AK. ZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor. PLoS One. 2013;8(1):e54477. PubMed PMID: 23372733; PubMed Central PMCID: PMC3556080. Collapse
Additional Publications
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