Assistant Professor, Cancer Prevention and Control Program
POSTDOCTORAL
EDUCATION
My current research focuses on identifying epigenomic determinants of lung cancer health disparities for precision medicine (considering environmental, lifestyle, and biological factors) purposes. Environmental radon exposure (the second-leading cause of lung cancer) has been linked to DNA methylation changes (an epigenomic modification). Racial differences in lung cancer risk may be compounded by the environment (high radon exposure), lifestyle (menthol tobacco smoking behaviors in African-Americans), and biology (Africa-American and European-American enriched DNA methylation patterns). I aim to provide direct evidence of radon-associated DNA methylation that impacts lung cancer risk in AAs and EAs, allowing for earlier detection.
12. 2019 Cobb J., Williams H., Mitchell K.A.
Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, San Francisco, CA, 9/23/2019.
“Predicting African American and European American patient response to kidney cancer immunotherapy by stage using the tumor microenvironment.”
11. 2018 Williams H., Mitchell K.A.
Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, New Orleans, LA, 11/2/2018.
“Integrative epigenomic and transcriptomic analyses of kidney cancers from African Americans and European Americans.”
10. 2018 McHayle A., Boles A., Diarra L., Mitchell K.A.
American Association for Cancer Research 109th Annual Meeting, Chicago, IL, 4/17/2018.
“Epigenetics, regulation of cancer immunotherapy response genes, and race: A comparison of DNA methylation in non-small cell lung cancers from African Americans and European Americans.”
9. 2017 Meaney C.*/Mitchell K.A.*, Zingone A., Brown D., Tang W., Yu Y., Cao L., Wenzlaff A.S., Schwartz A. G., Ryan B.
American Association for Cancer Research 108th Annual Meeting, Washington, DC, 4/4/2017. *Authors contributed equally
"Inflammatory based diagnostic markers of lung cancer in African Americans."
8. 2017 Ryan B., Loher P., Mitchell K.A., Zingone A., Zhao Y., Shetty J., Tran B., Rigoutsos I.
American Association for Cancer Research 108th Annual Meeting, Washington, DC, 4/4/2017.
"Deep sequencing of lung cancer samples using different library preparation methods produces discordant short non-coding RNA profiles."
7. 2016 Meaney C.*/Mitchell K.A.*, Zingone A., Brown D., Tang W., Yu Y., Cao L., Ryan B.
Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Fort Lauderdale, FL, 9/26/ 2016. *Authors contributed equally
"Inflammatory-based diagnostic markers of lung cancer in African Americans."
6. 2016 Mitchell K.A., Zingone A., Ryan B.
31st Aspen Cancer Conference, Aspen, CO, 7/18/2016.
"Unraveling the lung cancer transcriptome."
5. 2015 Mitchell K.A., Zingone A., Ryan B.
Eighth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA, 11/14/ 2015.
"Lung cancer in African Americans is characterized by histone modifying enzyme gene signatures."
4. 2015 Leikin J., Zingone A., Brown D., Mitchell K.A., Khan M., Vidal O., and Ryan B.
AACR 106th Annual Meeting, Philadelphia, PA, 4/2015.
"Analysis of miR-21 isomiRs in lung cancer."
3. 2005 Mitchell K.A., Johnston D., Trun N.
American Society for Microbiology Allegheny Branch Fall Meeting, Clearfield, PA, 11/2005.
“An Investigation of the mRNA Abundance and Expression Patterns for the Nine csp Genes in E. coli K-12.”
7/13
2. 2005 Mitchell K.A., Johnston D., Trun N.
University of Pittsburgh Science 2005: The New Research Ecology, Pittsburgh, PA, 10/2005.
“An Investigation of the mRNA Abundance and Expression Patterns for the Nine csp Genes in E. coli K-12.”
1. 2002 Mitchell K.A., Floyd J., Winkler L.
American Association for Physical Anthropology 71st Annual Meeting, Buffalo, NY, 4/13/2002.
“Adaptive strategies and resource utilization of the mantled howling monkey (Alouatta palliata) in a small forest fragment in Nicaragua.”
Campus (Peer-Reviewed Abstracts)
5. 2015 Mitchell K.A., Zingone A., Ryan B.
NCI Symposium on Chromosome Biology: Chromatin, ncRNA, Methylation & Disease Symposium, Bethesda, MD, 4/16/2015.
"A Histone Modifying Enzyme Gene Signature in Lung Tumors from African Americans."
4. 2015 Mitchell K.A., Zingone A., Ryan B.
15th Annual CCR Fellows and Young Investigator Colloquium, Rockville, MD, 3/23/2015.
"A Comprehensive Molecular Characterization of Lung Cancer Disparities."
3. 2014 Mitchell K.A., Noon M., Easwaran H., Baylin S.
National Human Genome Research Institute Advances in Genomics Research Summer Program, Bethesda, MD, 8/5/2014.
"DNMT3B (a de novo DNA methyltransferase) epigenetically regulates gene expression, independent of its DNA methyltransferase activity."
2. 2014 Mitchell K.A., Noon M., Easwaran H., Baylin S.
Burroughs Wellcome Fund Maryland Genetic, Epidemiology, and Medicine (MD-GEM) Genetics Research Day, Baltimore, MD, 2/28/2014.
"DNMT3B (a de novo DNA methyltransferase) epigenetically regulates gene expression, independent of its DNA methyltransferase activity."
1. 2006 Mitchell K.A., Brown J., Pei W., Feldman B.
National Human Genome Research Institute Annual Scientific Retreat, Gettysburg, PA, 11/2006.
“Visualizing RNA expression in early zebrafish embryos: a pilot study.”
Patient comments