Erica Golemis, PhD

Link to

This Fox Chase professor participates in the Undergraduate Summer Research Fellowship. 
Learn more about Research Volunteering.

Professor

Vice President

Associate Director for Systemwide Integration

Senior Associate Dean of Research, Lewis Katz School of Medicine at Temple University

Chair, Department of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University

William Wikoff Smith Chair in Cancer Research

Fellow, AAAS

 

Research Program

Educational Background

  • Post-Doctoral Studies, (yeast biotechnology/development of a two-hybrid system) , Massachusetts General Hospital Department of Molecular Biology and Harvard Medical School Department of Genetics, 1993
  • PhD, Biology (retroviruses and leukemogenesis), Massachusetts Institute of Technology, 1988
  • BA, Biology and English, Bryn Mawr College, 1983

Memberships

  • Member, American Society for Cell Biology (ASCB)
  • Member, American Association for Cancer Research (AACR)
  • Member, American Association for the Advancement of Science (AAAS)

Honors & Awards

  • American Cancer Society, Southeast Pennsylvania: Award for Scientific Accomplishment
  • Michael J. Brody Lecturer, University of Iowa College of Medicine
  • Session Chair, Keystone Meeting on Cilia, Tahoe City, CA
  • International Keynote Speaker, Hunter Meeting, Sydney, Australia
  • Award for Translational Science, Temple University School of Medicine
  • William Wikoff Smith Foundation, Endowed Chair in Cancer Research
  • Fellow, American Association for the Advancement of Science
  • Editor in Chief, Cancer & Metastasis Reviews

People

Additional Staff

Laboratory Alumni/ae

Anna S. Nikonova, PhD - research associate

Sanjeevani Arora, PhD - postdoc

Tim Beck – MD/PhD, graduate student

Margret B. Einarson, PhD - postdoc

Sarah Fashena, PhD - postdoc

Yayi Feng,  MS, grad student

Anna Gaponova, PhD - grad student

Eugene Izumchenko, PhD - grad student

Leonid Kharin, MD, Visiting Scientist

Vladimir Khazak, PhD - postdoc

Meghan Kopp, MS grad student

Anna Kiseleva, PhD, grad student

Vlad Korobeynikov, MS, grad student

Susan Law, PhD - postdoc

Joy L. Little, PhD - postdoc

Hanqing Liu, PhD - postdoc

Rochelle Nasto, PhD - grad student

Geraldine M. O'Neill, PhD - postdoc

Olga V. Plotnikova, PhD - grad student

Elena N. Pugacheva, PhD - postdoc

Vladimir Ratushny, MD, PhD - grad student

Tamina Seeger-Nukpezah, MD, PhD - postdoc

Victoria Serzhanova - MS grad student

Natalya Skobeleva, MD, PhD - Research Associate

Danlin Sun, MS grad student

Nadezhda (Nadya) Tikhmyanova, PhD - grad student

Rossella Tricarico, PhD – Visiting Scientist

Garabet Toby, PhD - grad student

Peishan Zhang, MS – grad student

Yu-Zhu Zhang, PhD - postdoc

Alexander Deneka, MD, PhD-  Research Associate

Mitchell Parker- MD. PhD Student, Drexel University College of Medicine

Shabnam Pirestani, MS

 

Former Lab Staff

Joanne Estojak, scientific technician

Wahiba Gherraby, scientific technician

 

Former Student Volunteers

Rihua Chen, volunteer

Adaeze Chikwem, MD, volunteer

Christiaan Honig, Volunteer, Germantown Academy, Fort Washington, PA

Sammi Hurley, Volunteer, University of Michigan, Ann Arbor, MI

Brook Neumann, volunteer

Ian E. Ochs, Volunteer, Germantown Academy

Katherine Xu, volunteer

Jennifer Cracchiolo, MD, Temple University School of Medicine

Nicolas G. Day, Student Assistant, St. John's College, Annapolis, MD

Sanat Deshpande, Wissahickon Senior High School

Louisa Eckman, Haverford College

Rachel Georgopoulos, Temple University School of Medicine

Timothy Kistner, Student Assistant

Rabuil Ryan, Student Assistant

David Sarcu, Temple University School of Medicine

Manali Shah, Student Assistant

Shelly Singh, University of Pittsburgh

Rahmat Sykder, volunteer

Zachary Smithline, Volunteer, Council Rock High School, Council Rock, PA

Zachary Wells, Student Assistant, Liberty College, Lynchburg, VA

Cecilia Zemanek, Student Assistant

Research Facility

Director, High Throughput Facility

Research Interests

  • Targeting signaling networks to improve therapy
  • The molecular basis for resistance to targeted anti-cancer agents
  • Interactions and activity of Aurora-A kinase

Lab Overview

The Golemis laboratory focuses on understanding factors contributing to the basis for aggressive tumor growth, and on evaluation of protein-targeted drugs, frequently collaborating with medical and radiation oncologists. To address these topics, the group uses bioinformatic analysis of very large genomic datasets to identify specific genetic features associated with specific patterns of therapeutic response in head and neck, lung, pancreatic and colorectal cancers. We integrate this work with use of animal models and cell-based strategies to elucidate the activity of signaling proteins and targeted therapies. We are particularly interested in investigating the Aurora-A kinase signaling axis in cancer and other pathological conditions.

Misc

Extramural Affiliations
  • Adjunct, Cell and Molecular Biology group, University of Pennsylvania
  • Adjunct, Department of Biochemistry, Drexel University School of Medicine
  • Adjunct, Department of Biochemistry, Lewis Katz School of Medicine, Temple University

Selected Publications

Deneka A.Y., Baca Y., Serebriiskii I.G., Nicolas E., Parker M.I., Nguyen T.T., Xiu J., Korn W.M., Demeure M.J., Wise-Draper T., Sukari A., Burtness B.,Golemis E.A., Association of tp53 and cdkn2a mutation profile with tumor mutation burden in head and neck cancer. Clin Cancer Res. 28(9): 1925-1937, 2022. https://www.ncbi.nlm.nih.gov/pubmed/35491653.

Serebriiskii I.G., Pavlov V., Tricarico R., Andrianov G., Nicolas E., Parker M.I., Newberg J., Frampton G., Meyer J.E.,Golemis E.A., Comprehensive characterization of pten mutational profile in a series of 34,129 colorectal cancers. Nat Commun. 13(1): 1618, 2022.PMC8956741. https://www.ncbi.nlm.nih.gov/pubmed/35338148.

Deneka A.Y., Kopp M.C., Nikonova A.S., Gaponova A.V., Kiseleva A.A., Hensley H.H., Flieder D.B., Serebriiskii I.G.,Golemis E.A., Nedd9 restrains autophagy to limit growth of early stage non-small cell lung cancer. Cancer Res. 81(13): 3717-3726, 2021.PMC8277748. https://www.ncbi.nlm.nih.gov/pubmed/34006524.

Gabitova-Cornell L, Surumbayeva A, Peri S, Franco-Barraza J, Restifo D, Weitz N, Ogier C, Goldman AR, Hartman TR, Francescone R, Tan Y, Nicolas E, Shah N, Handorf EA, Cai KQ, O'Reilly AM, Sloma I, Chiaverelli R, Moffitt RA, Khazak V, Fang CY, Golemis EA, Cukierman E, Astsaturov I. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020 Oct 12;38(4):567-583.e11, PMID: 32976774, PMCID: PMC7572882.

Deneka, A.Y., Einarson, M.B., Bennett, J., Nikonova, A.S., Elmekawy, M., Zhou, Y., Lee, J.W., Burtness, B.A., and Golemis E.A. Synthetic lethal targeting of mitotic checkpoints in HPV-negative head and neck cancer.  Cancers (Basel). 2020 Jan 28;12(2). pii: E306. doi: 10.3390/cancers12020306. PMID: 32012873, PMCID: PMC7072436

Tricarico, R., Nicolas, E., Hall, M.J., and Golemis, E.A. X- and Y-linked chromatin-modifying genes as regulators of sex-specific cancer incidence and prognosis.  Clin Cancer Res, 2020 Nov 1;26(21):5567-5578, PMID: 32732223, PMCID: PMC7642178

Serebriiskii, I.G., Connelly, C., Frampton, G., Newberg, J., Cooke, M., Miller, V., Ali, S., Ross, J., Handorf, E., Arora, S., Lieu, C., Golemis, E.A., and Meyer, J.E. RAS mutational profile differs between colon and rectal cancers, and in old versus young patients. Nat Commun, 2019 Aug 19;10(1):3722. doi: 10.1038/s41467-019-11530-0. PMID: 31427573, PMCID: PMC6700103.

Kiseleva, A.A., Korobeynikov, V.A., Deneka, A.Y., Nikonova, A.S., Zhang, P., Makhov, P., Einarson, M.B., Kolenko, V., Serebriiskii, I.G., Liu, H., Peterson, J.R., and Golemis, E.A. Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs. Clin Cancer Res, 2019 Mar 13. pii: clincanres.3535.2018. doi: 10.1158/1078-0432.CCR-18-3535. [Epub ahead of print] PMID: 30867219, PMCID: PMC6606352.

Lieu, C., Golemis, E., Serebriiskii, I., Newberg, J., Hemmerich, A., Connelly, C., Messersmith, W., Eng, C., Eckhardt, S.G., Frampton, G., Cooke, M., and Meyer, J. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer, Clinical Cancer Research, Oct 1;25(19):5852-5858., PMID: 31243121, PMCID: PMC6774873.

Lee, J.W., Parameswaran, J., Sandoval-Schaefer, T., Eoh, K.J., Yang, D., Zhu, F., Mehra, R., Sharma, R., Gaffney, S.G., Perry, E.B., Townsend, J.P., Serebriiskii, I.G., Golemis E.A., Issaeva, N., Yarbrough, W.G., Koo, J.S., and Burtness, B. Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck. Clin Cancer 2019 Jun 1;25(11):3430-3442. doi: 10.1158/1078-0432. PMID:30755439, PMCID: PMC6548643

... Expand

Additional Publications

My NCBI

The following ratings and reviews are based on verified feedback collected from independently administered patient experience surveys. The ratings and comments submitted by patients reflect their own views and opinions. Patient identities are withheld to ensure confidentiality and privacy. Learn more about our Patient Experience Ratings.

Ratings Breakdown

Loading ...

Patient comments

Loading ...
Resize Text

This Fox Chase professor participates in the Undergraduate Summer Research Fellowship. 
Learn more about Research Volunteering.

Related Articles

00 / 00