Fox Chase Cancer Center News

Fox Chase Cancer Center Remembers Nobel Laureate and Scientist Irwin “Ernie” Rose, 1926-2015

PHILADELPHIA (June 3, 2015) — Scientist and Nobel Laureate Irwin “Ernie” Rose, PhD, passed away June 2, 2015, after a long illness. He was 88. Rose shared the 2004 Nobel Prize for chemistry with Aaron Ciechanover and Avram Hershko of the Israel Institute of Technology for their pioneering work in discovering the ubiquitin conjugating system. Rose conducted this research as a senior scientist at Fox Chase Cancer Center in Philadelphia, where he worked from 1963 until he retired in 1995.

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Pembrolizumab may be Promising Treatment for Urothelial Cancer

CHICAGO (June 1, 2015) — The goal of many cancer researchers is to find effective treatments that have few adverse effects. Researchers at Fox Chase Cancer Center in Philadelphia in collaboration with co-investigators at other centers and Merck Inc. are one step closer to finding such a treatment for urothelial cancer, for which chemotherapy is currently the standard of care.

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Increasing Body Mass Index Linked with Worse Localized Prostate Cancer Outcomes

PHILADELPHIA (May 29, 2015) — An increasing body mass index (BMI) was associated with a higher rate of prostate cancer relapse, prostate cancer death, and death from any cause among men treated with dose-escalated intensity-modulated radiotherapy for localized prostate cancer, according to the results of a retrospective study by Fox Chase Cancer Center researchers.

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Patient interest, willingness to pay out of pocket costs for tumor genetic profiling assessed by Fox Chase researchers

CHICAGO (May 21, 2015) — Although recent survey participants expressed an interest in comprehensive tumor genetic profiling (CGP)—a novel technology to help identify mutations in pathologically relevant cancer genes for targeted therapy—the participants with lower income, less education, and non-private insurance were less likely to pursue CGP if out-of-pocket costs were involved, according to recent study findings.

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Next Generation Sequencing-Based Tumor Genomic Profiling Aids in Detecting Hereditary Variants in Cancer Risk Genes

CHICAGO (May 20, 2015) — Cancer patients are increasingly having their tumors tested using comprehensive genomic profiling (CGP) to identify genetic mutations that can be targeted by precision therapies. A new study from investigators at Fox Chase Cancer Center in collaboration with Foundation Medicine has shown that 3-7% of patients receiving CGP could have a genetic mutation that they inherited from a parent that can also be identified using results from next generation sequencing (NGS)-based CGP.

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