Newly Discovered Cause of Drug Resistance Could Improve Outcomes for Breast and Ovarian Cancer
PHILADELPHIA (May 1, 2016) — Many patients with breast or ovarian cancer initially benefit from DNA-damaging chemotherapies, but it has not been clear why these treatments lose effectiveness over time. In a new study, Fox Chase Cancer Center researchers showed that patients with mutations affecting a specific portion of the BRCA1 gene were susceptible to a new pathway of resistance to DNA-damaging drugs, including PARP inhibitors and platinum compounds.