Finding by Cancer Researchers Will Help Identify New Targets for Treatment of Autoimmune Diseases
PHILADELPHIA (March 11, 2019) — Adhesion of lymphocytes to their cellular targets is critical to adaptive immunity, the body’s ability to assign specific antibodies to pathogens. RAP1 function can be suppressed if its effector protein (RIAM) adopts an autoinhibitory configuration, and this suppression of RAP1 function is released once RIAM is phosphorylated.